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Plants versus medication

I've given up on medicating my tank for a fish disease that I/stores
haven't been able to remedy.  I'd like to remove the remaining fish and
treat the tank with something very aggressive.  Has anyone experienced
using something that would really do the trick, whatever the disease is,
but won't jeopardize my plants too badly.  I don't want to pull up all my
plants if at all possible, but then again, I don't want them to die either.
Is this possible???