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Re: bga MIC

Well I guess in pharmacy school they teach you more
about the drug and less about the bug :-) I went to
school for Clinical lab science, and am familiar with
MIC and all of that. A danger that you seem to be
overlooking is that of needless exposure to
antibiotics. What I mean by this is that while you may
use the exactly correct methodology for the killing of
BGA, you may just be giving some mycobacteria or
enterobacteria a nice antibiotic "bath". This results
in a pathogen with immunity that can be devestating.
Another problem is that of genetic transfer amongst
different species of bacteria. According to some
studies that I read back in my college days(5 or 6
years ago), bacteria in the same proximity can
transfer genetic material between species through
various means that we do not need to get into on a
plant list. There are pathogenic bacteria in your
aquarium (I believe Wright Huntley can attest to
that!), so please try to avoid antibiotics. Especially
for things that can be done by other methods.


Date: Mon, 7 May 2001 07:31:48 -0700 (PDT)
From: "L. Merrell" <merrell at u_washington.edu>
Subject: Re: bga MIC

Thanks for your insights. I am well aware of the risks
of undertreating
bacterial infections (I'm a pharmacy student, proper
use of antibiotics
is my mantra).  I treated the tank with 2.5mg/L as
recommended and it
worked like a charm.  There seems to be some
controversy regarding that
dosage and I was curious about the science behind the
dose.  Generally
one determines the MIC (minimum inhibitory
concentration) and then 
ensures that concentration stays well above that level
or that a 
amount of time is spent above the MIC ( concentration
vs time dependent
killing) depending on the drug in question.  I just
wanted to crunch 
Laurel Merrell
3rd Year Pharmacy Student
University of Washington Seattle,
WA http://students.washington.edu/merrell/aquaria.htm

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